Identity threshold used in MICRA

By default, MICRA runs in automatic mode with identity threshold depending of the antibiotic classes. These values were extracted from the Antibiotic Resistance Genes Database.

Antibiotic type BLAST cutoff Class name Description Drugs
dfra2095%dfraGroup A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.[trimethoprim]
vanxyc80%vancVanC type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.[vancomycin]
bl2be_ctxm75%bla_aClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [ceftazidime, cephalosporin_i, cephalosporin_ii, cephalosporin_iii, monobactam, penicillin]
bl1_ampc80%bla_cClass C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [cephalosproin]
bcrc80%bcrABC transporter system, bacitracin efflux pump. [bacitracin]
smeb80%smeabcResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[fluoroquinolone]
bcra80%bcrABC transporter system, bacitracin efflux pump. [bacitracin]
smea80%smeabcResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[fluoroquinolone]
smed80%smedefResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[fluoroquinolone]
bl2b_rob80%bla_aClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [cephalosproin, penicillin]
smec80%smeabcResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[fluoroquinolone]
aph3vb85%aphAminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.[neomycin, paromomycin, ribostamycin]
smef80%smedefResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[fluoroquinolone]
adec80%adeabcResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[aminoglycoside, chloramphenicol]
aph3va85%aphAminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.[neomycin, paromomycin, ribostamycin]
smee80%smedefResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[fluoroquinolone]
aac6i80%aacAminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation. [amikacin, dibekacin, isepamicin, netilmicin, sisomicin, tobramycin]
adeb80%adeabcResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[aminoglycoside, chloramphenicol]
bl2d_r3980%bla_dClass D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [cloxacillin, penicillin]
aac6iia90%aacAminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation. [dibekacin, gentamicin, netilmicin, sisomicin, tobramycin]
aac6iib80%aacAminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation. [dibekacin, gentamicin, netilmicin, sisomicin, tobramycin]
catb595%catbGroup B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.[chloramphenicol]
catb495%catbGroup B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.[chloramphenicol]
catb385%catbGroup B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.[chloramphenicol]
catb295%catbGroup B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.[chloramphenicol]
fusb80%fusbInvolved in the resistance (detoxification) of the fungal toxin fusaric acid.[fusaric_acid]
catb195%catbGroup B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.[chloramphenicol]
dfra2695%dfraGroup A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.[trimethoprim]
aac3vii80%aacAminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation. [paromomycin]
dfra2595%dfraGroup A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.[trimethoprim]
dfra2495%dfraGroup A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.[trimethoprim]
dfra2395%dfraGroup A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.[trimethoprim]
dfra2295%dfraGroup A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.[trimethoprim]
dfra2196%dfraGroup A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.[trimethoprim]
fush80%fushEsterase enzyme inactivating fusidic acid[fusidic_acid]
tolc80%acrResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[acriflavin, aminoglycoside, beta_lactam, glycylcycline, macrolide]
emre80%emreMultidrug resistance efflux pump.[aminoglycoside]
emrd80%emrdMultidrug resistance efflux pump.[]
bl2b_tem95%bla_aClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [cephalosporin, penicillin]
cata882%cataGroup A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.[chloramphenicol]
cata790%cataGroup A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.[chloramphenicol]
cata985%cataGroup A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.[chloramphenicol]
cata495%cataGroup A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.[chloramphenicol]
dfra1995%dfraGroup A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.[trimethoprim]
cata395%cataGroup A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.[chloramphenicol]
cata695%cataGroup A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.[chloramphenicol]
cata595%cataGroup A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.[chloramphenicol]
dfra1595%dfraGroup A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.[trimethoprim]
mefa80%mls_mfsMajor facilitator superfamily transporter, Macrolide-Lincosamide-Streptogramin B efflux pump.[macrolide]
bl1_cmy280%bla_cClass C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [carbapenem, cefoxitin, ceftazidime, ceftriaxone, cephalosporin, cephamycin]
dfra1495%dfraGroup A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.[trimethoprim]
cata290%cataGroup A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.[chloramphenicol]
dfra1795%dfraGroup A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.[trimethoprim]
cata195%cataGroup A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.[chloramphenicol]
dfra1695%dfraGroup A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.[trimethoprim]
dfra1095%dfraGroup A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.[trimethoprim]
dfra1396%dfraGroup A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.[trimethoprim]
dfra1295%dfraGroup A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.[trimethoprim]
bl2a_pc80%bla_aClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [penicillin]
bl2f_sme180%bla_aClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [carbapenem, cephalosproin, penicillin]
bl2e_y5680%bla_aClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [cephalosproin]
mdtl80%mdtlMajor facilitator superfamily transporter. Multidrug resistance efflux pump.[chloramphenicol]
bl2a_iii280%bla_aClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [penicillin]
mdtk80%mdtkMajor facilitator superfamily transporter. Multidrug resistance efflux pump.[enoxacin, norfloxacin]
mdth80%mdthMajor facilitator superfamily transporter. Multidrug resistance efflux pump.[deoxycholate, fosfomycin]
mdtg80%mdtgMajor facilitator superfamily transporter. Multidrug resistance efflux pump.[deoxycholate, fosfomycin]
mdtf80%mdtefResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[doxorubicin, erythromycin]
mdte80%mdtefResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[doxorubicin, erythromycin]
baca30%bacaUndecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate. [bacitracin]
aac3x80%aacAminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation. [aminoglycoside]
blt80%bltMajor facilitator superfamily transporter. Multidrug resistance efflux pump.[chloramphenicol, doxorubicin, fluoroquinolone, puromycin]
tcr380%tet_effluxMajor facilitator superfamily transporter, tetracycline efflux pump.[tetracycline]
mdto80%mdtnopResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[acriflavine, puromycin, t_chloride]
mdtp80%mdtnopResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[acriflavine, puromycin, t_chloride]
mdtm80%mdtmMajor facilitator superfamily transporter. Multidrug resistance efflux pump.[acriflavine, chloramphenicol, norfloxacin]
mdtn80%mdtnopResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[acriflavine, puromycin, t_chloride]
bl1_fox80%bla_cClass C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [cephalosproin]
bl2e_cbla80%bla_aClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [cephalosproin]
bl1_och80%bla_cClass C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [cephalosporin]
ble95%bleBinding protein with a strong affinity to the bleomycin family of antibiotics, which confers resistance to these antibiotics by preventing the bleomycin-induced DNA breakage[bleomycin]
qac80%qacSmall Multidrug Resistance (SMR) protein family. Multidrug resistance efflux pump, which consists of two proteins.[qa_compound]
bl2a_okp93%bla_aClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [penicillin]
aadd80%antAminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation. [kanamycin, tobramycin]
emea80%emeaMajor facilitator superfamily transporter. Multidrug resistance efflux pump.[fluoroquinolone]
aac6ia80%aacAminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation. [amikacin, dibekacin, isepamicin, netilmicin, sisomicin, tobramycin]
aac6ie80%aacAminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation. [amikacin, dibekacin, isepamicin, netilmicin, sisomicin, tobramycin]
cara80%mls_abcABC transporter system, Macrolide-Lincosamide-Streptogramin B efflux pump. [lincosamide, macrolide, streptogramin_b]
aac6ic80%aacAminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation. [amikacin, dibekacin, isepamicin, netilmicin, sisomicin, tobramycin]
aac6ib85%aacAminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation. [amikacin, dibekacin, isepamicin, netilmicin, sisomicin, tobramycin]
bl2d_oxa180%bla_dClass D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [cloxacillin, penicillin]
cata1695%cataGroup A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.[chloramphenicol]
bl2d_oxa280%bla_dClass D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [cloxacillin, penicillin]
cata1395%cataGroup A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.[chloramphenicol]
opra80%amrResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[acriflavine, aminoglycoside, macrolide]
cata1295%cataGroup A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.[chloramphenicol]
oprd80%mexhiResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[]
cata1595%cataGroup A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.[chloramphenicol]
bl3_cit80%bla_bClass B beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [carbapenem, cephalosporin, cephamycin, penicillin]
cata1495%cataGroup A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.[chloramphenicol]
cata1195%cataGroup A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.[chloramphenicol]
vanug80%vangVanG type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.[vancomycin]
cata1095%cataGroup A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.[chloramphenicol]
oprj80%mexcdResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[erythromycin, fluoroquinolone, glycylcycline, roxithromycin]
bl3_sim80%bla_bClass B beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [carbapenem, cephalosporin, cephamycin, penicillin]
aac6if80%aacAminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation. [amikacin, dibekacin, isepamicin, netilmicin, sisomicin, tobramycin]
aac6ig80%aacAminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation. [amikacin, dibekacin, isepamicin, netilmicin, sisomicin, tobramycin]
vgaa80%mls_abcABC transporter system, Macrolide-Lincosamide-Streptogramin B efflux pump. [streptogramin_a]
oprn80%mexefResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[chloramphenicol, fluoroquinolone]
bl1_sm60%bla_cClass C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [cephalosproin]
oprm80%mexabResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[aminoglycoside, beta_lactam, fluoroquinolone, tetracycline, tigecycline]
ykkc80%ykkSmall Multidrug Resistance (SMR) protein family. Multidrug resistance efflux pump, which consists of two proteins.[na_antimicrobials]
ykkd80%ykkSmall Multidrug Resistance (SMR) protein family. Multidrug resistance efflux pump, which consists of two proteins.[na_antimicrobials]
vgab80%mls_abcABC transporter system, Macrolide-Lincosamide-Streptogramin B efflux pump. [streptogramin_a]
tet_u280%tet_effluxMajor facilitator superfamily transporter, tetracycline efflux pump.[tetracycline]
ermd80%ermrRNA adenine N-6-methyltransferase, which can methylate adenine at position 2058 of 23S rRNA, conferring resistance to erythromycin.[lincosamide, macrolide, streptogramin_b]
tet_u180%tet_effluxMajor facilitator superfamily transporter, tetracycline efflux pump.[tetracycline]
aad980%antAminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation. [spectomycin, streptomycin]
dfra795%dfraGroup A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.[trimethoprim]
erme80%ermrRNA adenine N-6-methyltransferase, which can methylate adenine at position 2058 of 23S rRNA, conferring resistance to erythromycin.[lincosamide, macrolide, streptogramin_b]
tet_u480%tet_rppRibosomal protection protein, which protects ribosome from the translation inhibition of tetracycline.[tetracycline]
ermf80%ermrRNA adenine N-6-methyltransferase, which can methylate adenine at position 2058 of 23S rRNA, conferring resistance to erythromycin.[lincosamide, macrolide, streptogramin_b]
tet_u380%tet_effluxMajor facilitator superfamily transporter, tetracycline efflux pump.[tetracycline]
dfra595%dfraGroup A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.[trimethoprim]
ermg80%ermrRNA adenine N-6-methyltransferase, which can methylate adenine at position 2058 of 23S rRNA, conferring resistance to erythromycin.[lincosamide, macrolide, streptogramin_b]
tet_u680%tet_effluxMajor facilitator superfamily transporter, tetracycline efflux pump.[tetracycline]
sta80%staStreptothricin acetyltransferase (STAT).[streptothricin]
tet_u580%tet_effluxMajor facilitator superfamily transporter, tetracycline efflux pump.[tetracycline]
aac3ia80%aacAminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation. [astromicin, gentamicin, sisomicin]
erma80%ermrRNA adenine N-6-methyltransferase, which can methylate adenine at position 2058 of 23S rRNA, conferring resistance to erythromycin.[lincosamide, macrolide, streptogramin_b]
otra80%tet_rppRibosomal protection protein, which protects ribosome from the translation inhibition of tetracycline.[tetracycline]
ermb80%ermrRNA adenine N-6-methyltransferase, which can methylate adenine at position 2058 of 23S rRNA, conferring resistance to erythromycin.[lincosamide, macrolide, streptogramin_b]
otrb80%tet_effluxMajor facilitator superfamily transporter, tetracycline efflux pump.[tetracycline]
dfra195%dfraGroup A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.[trimethoprim]
ermc90%ermrRNA adenine N-6-methyltransferase, which can methylate adenine at position 2058 of 23S rRNA, conferring resistance to erythromycin.[lincosamide, macrolide, streptogramin_b]
tlrc80%mls_abcABC transporter system, Macrolide-Lincosamide-Streptogramin B efflux pump. [lincosamide, macrolide, streptogramin_b]
ermn80%ermrRNA adenine N-6-methyltransferase, which can methylate adenine at position 2058 of 23S rRNA, conferring resistance to erythromycin.[lincosamide, macrolide, streptogramin_b]
ermo80%ermrRNA adenine N-6-methyltransferase, which can methylate adenine at position 2058 of 23S rRNA, conferring resistance to erythromycin.[lincosamide, macrolide, streptogramin_b]
ermh80%ermrRNA adenine N-6-methyltransferase, which can methylate adenine at position 2058 of 23S rRNA, conferring resistance to erythromycin.[lincosamide, macrolide, streptogramin_b]
tsnr80%tsnrSpecifically methylates the adenosine-1067 in 23S ribosomal RNA. Confers resistance to antibiotic thiostrepton.[thiostrepton]
tcma65%tcmaMajor facilitator superfamily transporter. Resistance to tetracenomycin C by an active tetracenomycin C efflux system which is probably energized by transmembrane electrochemical gradients.[tetracenomycin_c]
ermu80%ermrRNA adenine N-6-methyltransferase, which can methylate adenine at position 2058 of 23S rRNA, conferring resistance to erythromycin.[lincosamide, macrolide, streptogramin_b]
aac2ib80%aacAminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation. [6_n_netilmicin, dibekacin, gentamicin, netilmicin, tobramycin]
ermt90%ermrRNA adenine N-6-methyltransferase, which can methylate adenine at position 2058 of 23S rRNA, conferring resistance to erythromycin.[lincosamide, macrolide, streptogramin_b]
aac2ic80%aacAminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation. [6_n_netilmicin, dibekacin, gentamicin, netilmicin, tobramycin]
aac3iv80%aacAminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation. [apramycin, dibekacin, gentamicin, netilmicin, sisomicin, tobramycin]
ermw80%ermrRNA adenine N-6-methyltransferase, which can methylate adenine at position 2058 of 23S rRNA, conferring resistance to erythromycin.[lincosamide, macrolide, streptogramin_b]
aac2id80%aacAminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation. [6_n_netilmicin, dibekacin, gentamicin, netilmicin, tobramycin]
bmr80%bmrMajor facilitator superfamily transporter. Multidrug resistance efflux pump.[chloramphenicol, fluoroquinolone]
ermv80%ermrRNA adenine N-6-methyltransferase, which can methylate adenine at position 2058 of 23S rRNA, conferring resistance to erythromycin.[lincosamide, macrolide, streptogramin_b]
aac3ix80%aacAminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation. [neomycin]
vante80%vaneVanE type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.[vancomycin]
str80%strStreptomycin resistance protein. [streptomycin]
ermq80%ermrRNA adenine N-6-methyltransferase, which can methylate adenine at position 2058 of 23S rRNA, conferring resistance to erythromycin.[lincosamide, macrolide, streptogramin_b]
vantg80%vangVanG type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.[vancomycin]
erms80%ermrRNA adenine N-6-methyltransferase, which can methylate adenine at position 2058 of 23S rRNA, conferring resistance to erythromycin.[lincosamide, macrolide, streptogramin_b]
ermr80%ermrRNA adenine N-6-methyltransferase, which can methylate adenine at position 2058 of 23S rRNA, conferring resistance to erythromycin.[lincosamide, macrolide, streptogramin_b]
dfrb195%dfrbGroup B drug-insensitive R67 dihydrofolate reductase, which can not be inhibited by trimethoprim.[trimethoprim]
ermy80%ermrRNA adenine N-6-methyltransferase, which can methylate adenine at position 2058 of 23S rRNA, conferring resistance to erythromycin.[lincosamide, macrolide, streptogramin_b]
ermx80%ermrRNA adenine N-6-methyltransferase, which can methylate adenine at position 2058 of 23S rRNA, conferring resistance to erythromycin.[lincosamide, macrolide, streptogramin_b]
vgbb80%mls_hdrStreptogramin B Lyase, which can deactivate the target drug by hydrolysis.[streptogramin_b]
ant4iia80%antAminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation. [amikacin, isepamicin, tobramycin]
vgba80%mls_hdrStreptogramin B Lyase, which can deactivate the target drug by hydrolysis.[streptogramin_b]
aac2ia80%aacAminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation. [6_n_netilmicin, dibekacin, gentamicin, netilmicin, tobramycin]
vatc80%vatVirginiamycin A acetyltransferase, which can inactivate the target drug.[streptogramin_a]
tet3480%tet_xprtXanthine-guanine phosphoribosyltransferase. Mechanism detail unknown.[tetracycline]
mexb80%mexabResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[aminoglycoside, beta_lactam, fluoroquinolone, tetracycline, tigecycline]
dfrb395%dfrbGroup B drug-insensitive R67 dihydrofolate reductase, which can not be inhibited by trimethoprim.[trimethoprim]
vatd80%vatVirginiamycin A acetyltransferase, which can inactivate the target drug.[streptogramin_a]
mexc80%mexcdResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[erythromycin, fluoroquinolone, glycylcycline, roxithromycin]
dfrb295%dfrbGroup B drug-insensitive R67 dihydrofolate reductase, which can not be inhibited by trimethoprim.[trimethoprim]
vata80%vatVirginiamycin A acetyltransferase, which can inactivate the target drug.[streptogramin_a]
tet3680%tet_rppRibosomal protection protein, which protects ribosome from the translation inhibition of tetracycline.[tetracycline]
vatb80%vatVirginiamycin A acetyltransferase, which can inactivate the target drug.[streptogramin_a]
tet3780%tet_flavoFlavoproteins. Mechanism detail unknown. Only one such protein found in oral metagenome. [tetracycline]
mexa80%mexabResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[aminoglycoside, beta_lactam, fluoroquinolone, tetracycline, tigecycline]
tet3080%tet_effluxMajor facilitator superfamily transporter, tetracycline efflux pump.[tetracycline]
mexf80%mexefResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[chloramphenicol, fluoroquinolone]
aph6id80%aphAminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.[streptomycin]
tet3180%tet_effluxMajor facilitator superfamily transporter, tetracycline efflux pump.[tetracycline]
dfrb695%dfrbGroup B drug-insensitive R67 dihydrofolate reductase, which can not be inhibited by trimethoprim.[trimethoprim]
vate80%vatVirginiamycin A acetyltransferase, which can inactivate the target drug.[streptogramin_a]
tet3285%tet_rppRibosomal protection protein, which protects ribosome from the translation inhibition of tetracycline.[tetracycline]
mexd80%mexcdResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[erythromycin, fluoroquinolone, glycylcycline, roxithromycin]
tet3380%tet_effluxMajor facilitator superfamily transporter, tetracycline efflux pump.[tetracycline]
mexe80%mexefResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[chloramphenicol, fluoroquinolone]
aph6ia80%aphAminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.[streptomycin]
mexh80%mexhiResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[]
aph6ib80%aphAminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.[streptomycin]
mexi80%mexhiResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[]
aph6ic80%aphAminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.[streptomycin]
tet3880%tet_effluxMajor facilitator superfamily transporter, tetracycline efflux pump.[tetracycline]
tet3980%tet_effluxMajor facilitator superfamily transporter, tetracycline efflux pump.[tetracycline]
sul180%sulSulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide. [sulfonamide]
bl1_ceps80%bla_cClass C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [cephalosporin]
vansg80%vangVanG type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.[vancomycin]
aph4ib80%aphAminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.[hygromycin_b]
vansd80%vandVanD type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.[teicoplanin, vancomycin]
vanse80%vaneVanE type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.[vancomycin]
bl3_ccra80%bla_bClass B beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [carbapenem, cephalosproin, cephamycin, penicillin]
vansb80%vanbVanB type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.[vancomycin]
mexw80%mexvwResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[]
vansc80%vancVanC type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.[vancomycin]
vansa80%vanaVanA type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.[teicoplanin, vancomycin]
tet4080%tet_effluxMajor facilitator superfamily transporter, tetracycline efflux pump.[tetracycline]
mexy80%mexxyResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[aminoglycoside, glycylcycline]
mexx80%mexxyResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[aminoglycoside, glycylcycline]
lsa80%lsaABC efflux family that is resistant to MLS antibiotics[lincosamide, macrolide, streptogramin_b]
sul380%sulSulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide. [sulfonamide]
sul280%sulSulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide. [sulfonamide]
lmrb80%mls_mfsMajor facilitator superfamily transporter, Macrolide-Lincosamide-Streptogramin B efflux pump.[lincomycin]
lmra80%mls_mfsMajor facilitator superfamily transporter, Macrolide-Lincosamide-Streptogramin B efflux pump.[lincomycin]
bl2d_oxa1095%bla_dClass D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [cloxacillin, penicillin]
bl2be_shv295%bla_aClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [e_cephalosproin, monobactam, n_cephalosproin, penicillin]
bl1_mox80%bla_cClass C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [cephalosproin]
aac3vi80%aacAminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation. [gentamicin, sisomicin]
qnra80%qnrPentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.[fluoroquinolone]
qnrb80%qnrPentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.[fluoroquinolone]
vanrc80%vancVanC type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.[vancomycin]
vanrd80%vandVanD type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.[teicoplanin, vancomycin]
vanre80%vaneVanE type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.[vancomycin]
bl2d_oxa980%bla_dClass D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [cloxacillin, penicillin]
bl3_shw50%bla_bClass B beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [carbapenem, cephalosporin, cephamycin, penicillin]
vanxye80%vaneVanE type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.[vancomycin]
vanxyg80%vangVanG type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.[vancomycin]
vanra80%vanaVanA type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.[teicoplanin, vancomycin]
vanrb80%vanbVanB type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.[vancomycin]
bl2d_oxa595%bla_dClass D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [cloxacillin, penicillin]
bl2e_cfxa80%bla_aClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [cephalosproin]
vanrg80%vangVanG type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.[vancomycin]
ceob80%ceoResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[chloramphenicol]
qnrs80%qnrPentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.[fluoroquinolone]
ceoa80%ceoResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[chloramphenicol]
pbp280%pbpThe enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)[penicillin]
vane80%vaneVanE type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.[vancomycin]
vanc80%vancVanC type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.[vancomycin]
bl2d_lcr180%bla_dClass D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [cloxacillin, penicillin]
vand80%vandVanD type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.[teicoplanin, vancomycin]
vang80%vangVanG type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.[vancomycin]
vanyg80%vangVanG type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.[vancomycin]
tetb80%tet_effluxMajor facilitator superfamily transporter, tetracycline efflux pump.[tetracycline]
teta85%tet_effluxMajor facilitator superfamily transporter, tetracycline efflux pump.[tetracycline]
fosx80%fosGlutathione transferase, metalloglutathione transferase which confers resistance to fosfomycin by catalyzing the addition of glutathione to fosfomycin[fosfomycin]
bl3_imp80%bla_bClass B beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [carbapenem, cephalosproin, cephamycin, penicillin]
bl2a_exo80%bla_aClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [penicillin]
vant80%vancVanC type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.[vancomycin]
vanya80%vanaVanA type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.[teicoplanin, vancomycin]
vanz80%vanzVanZ confers low-level VanZ confers low-level resistance to the glycopeptide antibiotic teicoplanin. [teicoplanin]
vanyb80%vanbVanB type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.[vancomycin]
norm80%normMulti antimicrobial extrusion (MATE) efflux family protein. Multidrug resistance efflux pump.[ciprofloxacin, kanamycin, norfloxacin, streptomycin, tigecycline]
vanyd80%vandVanD type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.[teicoplanin, vancomycin]
oleb80%mls_abcABC transporter system, Macrolide-Lincosamide-Streptogramin B efflux pump. [lincosamide, macrolide, streptogramin_b]
aph3via80%aphAminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.[amikacin, butirosin, gentamicin_b, isepamicin, kanamycin, neomycin, paromomycin, ribostamycin]
tetx80%tet_modNADP-requiring oxidoreductase, an enzyme that can modify tetracycline. Mechanism detail unknown.[tetracycline]
ant6ia80%antAminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation. [streptomycin]
tetw81%tet_rppRibosomal protection protein, which protects ribosome from the translation inhibition of tetracycline.[tetracycline]
amra80%amrResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[acriflavine, aminoglycoside, macrolide]
bl2f_nmca80%bla_aClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [carbapenem, cephalosproin, penicillin]
bl3_cpha80%bla_bClass B beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [carbapenem, cephalosporin, cephamycin, penicillin]
tetz80%tet_effluxMajor facilitator superfamily transporter, tetracycline efflux pump.[tetracycline]
tety80%tet_effluxMajor facilitator superfamily transporter, tetracycline efflux pump.[tetracycline]
tett80%tet_rppRibosomal protection protein, which protects ribosome from the translation inhibition of tetracycline.[tetracycline]
tets85%tet_rppRibosomal protection protein, which protects ribosome from the translation inhibition of tetracycline.[tetracycline]
tetv80%tet_effluxMajor facilitator superfamily transporter, tetracycline efflux pump.[tetracycline]
amrb80%amrResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[acriflavine, aminoglycoside, macrolide]
tetu80%tet_otherTetracycline resistance other mechanisms. [tetracycline]
bl3_l80%bla_bClass B beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [carbapenem, cephalosproin, cephamycin, penicillin]
lnua80%lnuLincosamide nucleotidyltransferase. [lincomycin]
bl1_acc80%bla_cClass C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [cephalosporin, e_penicillin]
lnub80%lnuLincosamide nucleotidyltransferase. [lincomycin]
aph3iiia80%aphAminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.[amikacin, butirosin, gentamincin_b, isepamicin, kanamycin, lividomycin, neomycin, paromomycin, ribostamycin]
tetg80%tet_effluxMajor facilitator superfamily transporter, tetracycline efflux pump.[tetracycline]
teth87%tet_effluxMajor facilitator superfamily transporter, tetracycline efflux pump.[tetracycline]
rosb80%rosabEfflux pump/potassium antiporter system. RosA: Major facilitator superfamily transporter. RosB: Potassium antiporter. [fosmidomycin]
tetj87%tet_effluxMajor facilitator superfamily transporter, tetracycline efflux pump.[tetracycline]
tetc85%tet_effluxMajor facilitator superfamily transporter, tetracycline efflux pump.[tetracycline]
vanxd80%vandVanD type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.[teicoplanin, vancomycin]
tetd80%tet_effluxMajor facilitator superfamily transporter, tetracycline efflux pump.[tetracycline]
rosa80%rosabEfflux pump/potassium antiporter system. RosA: Major facilitator superfamily transporter. RosB: Potassium antiporter. [fosmidomycin]
vanxa85%vanaVanA type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.[teicoplanin, vancomycin]
tete80%tet_effluxMajor facilitator superfamily transporter, tetracycline efflux pump.[tetracycline]
fosa80%fosGlutathione transferase, metalloglutathione transferase which confers resistance to fosfomycin by catalyzing the addition of glutathione to fosfomycin[fosfomycin]
vanxb85%vanbVanB type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.[vancomycin]
teto85%tet_rppRibosomal protection protein, which protects ribosome from the translation inhibition of tetracycline.[tetracycline]
fosc80%fosGlutathione transferase, metalloglutathione transferase which confers resistance to fosfomycin by catalyzing the addition of glutathione to fosfomycin[fosfomycin]
fosb60%fosGlutathione transferase, metalloglutathione transferase which confers resistance to fosfomycin by catalyzing the addition of glutathione to fosfomycin[fosfomycin]
bl3_vim70%bla_bClass B beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [carbapenem, cephalosporin, cephamycin, penicillin]
tetq80%tet_rppRibosomal protection protein, which protects ribosome from the translation inhibition of tetracycline.[tetracycline]
tetk80%tet_effluxMajor facilitator superfamily transporter, tetracycline efflux pump.[tetracycline]
tetl80%tet_effluxMajor facilitator superfamily transporter, tetracycline efflux pump.[tetracycline]
vanb80%vanbVanB type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.[vancomycin]
tetm85%tet_rppRibosomal protection protein, which protects ribosome from the translation inhibition of tetracycline.[tetracycline]
vana80%vanaVanA type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.[teicoplanin, vancomycin]
bl2a_iii80%bla_aClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [penicillin]
vanwg80%vangVanG type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.[vancomycin]
aph3viia80%aphAminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.[kanamycin, neomycin]
vanwb80%vanbVanB type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.[vancomycin]
ant3ia90%antAminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation. [spectinomycin, streptomycin]
opcm80%ceoResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[chloramphenicol]
bl2c_pse380%bla_aClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [carbenicillin, penicillin]
bl2c_pse180%bla_aClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [carbenicillin, penicillin]
srmb80%mls_abcABC transporter system, Macrolide-Lincosamide-Streptogramin B efflux pump. [lincosamide, macrolide, streptogramin_b]
msra80%mls_abcABC transporter system, Macrolide-Lincosamide-Streptogramin B efflux pump. [lincosamide, macrolide, streptogramin_b]
aph3ia80%aphAminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.[gentamincin_b, kanamycin, lividomycin, neomycin, paromomycin, ribostamycin]
aph3ib80%aphAminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.[gentamincin_b, kanamycin, lividomycin, neomycin, paromomycin, ribostamycin]
aph3ic80%aphAminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.[gentamincin_b, kanamycin, lividomycin, neomycin, paromomycin, ribostamycin]
bl3_gim80%bla_bClass B beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [carbapenem, cephalosporin, cephamycin, penicillin]
aad9ib80%antAminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation. [spectomycin, streptomycin]
bl2e_cepa80%bla_aClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [cephalosproin]
mecr180%mecr1Methicillin-resistance regulatory protein for mecA[methicillin]
bl2be_per80%bla_aClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [e_cephalosproin, monobactam, n_cephalosproin, penicillin]
mphc80%mphMacrolide phosphotransferase[macrolide]
mphb80%mphMacrolide phosphotransferase[macrolide]
mpha80%mphMacrolide phosphotransferase[macrolide]
bl2b_tem1100%bla_aClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [cephalosporin_i, cephalosporin_ii, penicillin]
adea80%adeabcResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[aminoglycoside, fluoramphenicol]
bl2b_tem2100%bla_aClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [cephalosporin_i, cephalosporin_ii, penicillin]
bl2a_kcc80%bla_aClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [penicillin]
bl1_ec80%bla_cClass C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [cephalosproin]
cml_e295%cmlMajor facilitator superfamily transporter, chloramphenicol efflux pump. [chloramphenicol]
cml_e390%cmlMajor facilitator superfamily transporter, chloramphenicol efflux pump. [chloramphenicol]
cml_e180%cmlMajor facilitator superfamily transporter, chloramphenicol efflux pump. [chloramphenicol]
aac3viii80%aacAminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation. [neomycin, ribostamycin]
acra80%acrResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[acriflavin, aminoglycoside, beta_lactam, glycylcycline, macrolide]
cml_e695%cmlMajor facilitator superfamily transporter, chloramphenicol efflux pump. [chloramphenicol]
cml_e780%cmlMajor facilitator superfamily transporter, chloramphenicol efflux pump. [chloramphenicol]
cml_e495%cmlMajor facilitator superfamily transporter, chloramphenicol efflux pump. [chloramphenicol]
acrb80%acrResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.[acriflavin, aminoglycoside, beta_lactam, glycylcycline, macrolide]
cml_e595%cmlMajor facilitator superfamily transporter, chloramphenicol efflux pump. [chloramphenicol]
cml_e895%cmlMajor facilitator superfamily transporter, chloramphenicol efflux pump. [chloramphenicol]
ksga80%ksgaSpecifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.[kasugamycin]
bl2_kpc80%bla_aClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [carbapenem, cephalosporin, cephamycin, penicillin]
aph33ib80%aphAminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.[streptomycin]
aph3iva80%aphAminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.[butirosin, kanamycin, neomycin, paromomycin, ribostamycin]
aph33ia80%aphAminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.[streptomycin]
pbp2x80%pbpThe enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)[penicillin]
maca80%macabResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system. [macrolide]
macb80%macabResistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system. [macrolide]
bl2be_oxy180%bla_aClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [monobactam, penicillin]
aac2i80%aacAminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation. [6_n_netilmicin, dibekacin, gentamicin, netilmicin, tobramycin]
pmra80%pmraMajor facilitator superfamily transporter. Multidrug resistance efflux pump.[ciprofloxacin, norfloxacin]
tet80%tet_rppRibosomal protection protein, which protects ribosome from the translation inhibition of tetracycline.[tetracycline]
ereb80%ereErythromycin esterase, which can inactivate erythromycin by lactone ring cleavage. [erythromycin]
bl2a_nps80%bla_aClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [penicillin]
erea80%ereErythromycin esterase, which can inactivate erythromycin by lactone ring cleavage. [erythromycin]
bl2d_moxa80%bla_dClass D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [cloxacillin, penicillin]
bl2c_bro80%bla_aClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [carbenicillin, penicillin]
bl2b_tle80%bla_aClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [cephalosproin, penicillin]
bl2b_ula80%bla_aClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [cephalosproin, penicillin]
aac3iib85%aacAminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation. [dibekacin, gentamicin, netilmicin, sisomicin, tobramycin]
ant2ia90%antAminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation. [dibekacin, gentamicin, kanamycin, sisomicin, tobramycin]
aac3iia85%aacAminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation. [dibekacin, gentamicin, netilmicin, sisomicin, tobramycin]
bl1_pse80%bla_cClass C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [cephalosporin]
ant2ib80%antAminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation. [dibekacin, gentamicin, kanamycin, sisomicin, tobramycin]
vanhd80%vandVanD type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.[teicoplanin, vancomycin]
qaca100%qacabMultidrug efflux pump from bacterial pathogen staphylococcus aureus. Including QacA and QacB, both of which confer resistance to various toxic organic cations but differ in that QacB mediates lower levels of resistance to divalent cations. They differed by seven nucleotide subsititutions. [qa_compound]
qacb99%qacabMultidrug efflux pump from bacterial pathogen staphylococcus aureus. Including QacA and QacB, both of which confer resistance to various toxic organic cations but differ in that QacB mediates lower levels of resistance to divalent cations. They differed by seven nucleotide subsititutions. [qa_compound]
vanhb80%vanbVanB type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.[vancomycin]
aac3iii80%aacAminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation. [dibekacin, gentamicin, kanamycin, lividomycin, neomycin, paromomycin, sisomicin, tobramycin]
vanha80%vanaVanA type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.[teicoplanin, vancomycin]
pbp2b80%pbpThe enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)[penicillin]
bl1_asba80%bla_cClass C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [cephalosproin]
bl2_ges80%bla_aClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [cephalosporin, penicillin]
tmrb80%tmrMechanism unknown. [tunicamycin]
bl1_pao80%bla_cClass C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [cephalosproin]
bl2_veb80%bla_aClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [cephalosporin, penicillin]
tetpb80%tet_rppRibosomal protection protein, which protects ribosome from the translation inhibition of tetracycline.[tetracycline]
tetpa80%tet_effluxMajor facilitator superfamily transporter, tetracycline efflux pump.[tetracycline]
meca80%mecaPenicillin binding protein, which has a low affinity for beta-lactams and catalyze a penicillin-insensitive transpeptidation.[beta_lactam]
arna80%arnaBifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.[polymyxin]
mfpa80%mfpaPentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.[fluoroquinolone]
vph80%vphViomycin phosphotransferase, which chieves inactivation of their antibiotic substrates by phosphorylation.[viomycin]
bl2a_180%bla_aClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [penicillin]
bl2e_fpm80%bla_aClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [cephalosproin]
bl2_len95%bla_aClass A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites. [penicillin]
mepa80%mepaMulti antimicrobial extrusion (MATE) efflux family protein. Multidrug resistance efflux pump.[tigecycline]
pbp1a80%pbpThe enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)[penicillin]
pbp1b80%pbpThe enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)[penicillin]